Alterations in the blood immune system found to increase cancer risk
Pleiotropic RNYs are linked to SLE risk and plasma RNYs are relatively abundant preceding breast cancer diagnosis. a Scatter plot of the correlation of the levels of expression between RO60 and the pleiotropic or non-pleiotropic RNY signatures in TCGA normal tissue. The PCCs and p values are indicated. b Graphs showing the number of variants (SNPs) identified as pleiotropic in RNYs (± 50 kb) and correlated (European r2 > 0.4, left panel; r2 > 0.8, right panel) with SLE GWAS catalog variants, and compared with the…
